Viruses can be transmitted through seedlings propagated via cuttings or grafting, whereas when propagated using the in vitro method, new seedlings are not infected by diseases. However, during subsequent growth stages, they may contract other diseases from external sources, requiring protective measures. The claim that mineral fertilizers are used 10 times less is not accurate; annual fertilization is necessary based on the agrochemical analysis of the soil and the expected yield.

When propagated using the in vitro method, only viruses are eliminated. The purpose is to prevent the transmission of viral diseases during the cutting or grafting process, i.e., during seedling cultivation. This protection is not lifelong, as grapevine seedlings can later become infected with viral diseases during their growth. In Uzbekistan's conditions, the primary grapevine diseases (powdery mildew, downy mildew, anthracnose) are fungal diseases, and the in vitro propagation method has no relevance to these diseases.

Currently, the only way to prevent these diseases is by using chemical treatments. If grapevine varieties resistant to these fungal diseases are developed through genetic modification, the use of chemical treatments could be reduced or completely eliminated. Unfortunately, such varieties have not yet been developed. Even if they are developed, they could potentially pose risks to human health.